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January 4, 2016

Aging Chart: a community resource for rapid exploratory pathway analysis of age-related processes. Nucleic Acids Res.

Written and published by Biogerontology Research Foundation staff in collaboration with Moscow Institute of Physics and Technology (Laboratory of Genetics of Aging and Longevity), Institute of Biology of Komi Science Center of Ural Branch of Russian Academy of Sciences (Laboratory of Molecular Radiobiology and Gerontology), Estonia Infinity Sciences, Inc., University of Tennessee Health Science Center (Department of Genetics, Genomics, and Informatics), and D.Rogachev FRC Center for Pediatric Hematology, Oncology and Immunology.

Aging Chart: a community resource for rapid exploratory pathway analysis of age-related processes. Nucleic Acids Res. 2016 Jan 4;44(D1):D894-9.

Moskalev A(1), Zhikrivetskaya S(2), Shaposhnikov M(3), Dobrovolskaya E(3), Gurinovich R(4), Kuryan O(5), Pashuk A(5), Jellen LC(6), Aliper A(7), Peregudov A(8), Zhavoronkov A(9).

(1) Laboratory of molecular radiobiology and gerontology, Institute of Biology of Komi Science Center of Ural Branch of Russian Academy of Sciences, Syktyvkar, 167982, Russia Laboratory of genetics of aging and longevity, Moscow Institute of Physics and Technology, Dolgoprudny, 141700, Russia Laboratory of postgenomic studies, Engelhardt Institute of Molecular Biology of Russian Academy of Sciences, Moscow, 119991, Russia School of Systems Biology, George Mason University, VA, Manassas, 20110, USA Branch of N.I.Pirogov Russian State Medical University "Scientific Clinical Center of Gerontology", Moscow, 117997, Russia amoskalev@list.ru.

(2) Laboratory of genetics of aging and longevity, Moscow Institute of Physics and Technology, Dolgoprudny, 141700, Russia Laboratory of postgenomic studies, Engelhardt Institute of Molecular Biology of Russian Academy of Sciences, Moscow, 119991, Russia.

(3) Laboratory of molecular radiobiology and gerontology, Institute of Biology of Komi Science Center of Ural Branch of Russian Academy of Sciences, Syktyvkar, 167982, Russia.

(4) Xpansa, Conzl OU, Mustamae Tee 5, Tallinn, 10616, Estonia Infinity Sciences, Inc, 16192 Coastal Highway, Lewes, Delaware, County of Sussex, 19958, USA amoskalev@list.ru.

(5) Xpansa, Conzl OU, Mustamae Tee 5, Tallinn, 10616, Estonia Infinity Sciences, Inc, 16192 Coastal Highway, Lewes, Delaware, County of Sussex, 19958, USA.

(6) Genetics, Genomics, and Informatics, University of Tennessee Health Science Center, Memphis, TN, 38163, USA.

(7) D.Rogachev FRC Center for Pediatric Hematology, Oncology and Immunology, Samory Machela 1, Moscow, 117997, Russia Insilico Medicine, Inc, Johns Hopkins University, ETC, B310, Baltimore, MD, 21218, USA.

(8) The Biogerontology Research Foundation, 2354 Chynoweth House, Trevissome Park, Blackwater, Truro, Cornwall TR4 8UN, UK.

(9) Laboratory of genetics of aging and longevity, Moscow Institute of Physics and Technology, Dolgoprudny, 141700, Russia; D.Rogachev FRC Center for Pediatric Hematology, Oncology and Immunology, Samory Machela 1, Moscow, 117997, Russia; Insilico Medicine, Inc.; Johns Hopkins University, ETC, B310, Baltimore, MD, 21218, USA; The Biogerontology Research Foundation, 2354 Chynoweth House, Trevissome Park, Blackwater, Truro, Cornwall TR4 8UN, UK amoskalev@list.ru.

Abstract: Aging research is a multi-disciplinary field encompassing knowledge from many areas of basic, applied and clinical research. Age-related processes occur on molecular, cellular, tissue, organ, system, organismal and even psychological levels, trigger the onset of multiple debilitating diseases and lead to a loss of function, and there is a need for a unified knowledge repository designed to track, analyze and visualize the cause and effect relationships and interactions between the many elements and processes on all levels. Aging Chart (http://agingchart.org/) is a new, community-curated collection of aging pathways and knowledge that provides a platform for rapid exploratory analysis. Building on an initial content base constructed by a team of experts from peer-reviewed literature, users can integrate new data into biological pathway diagrams for a visible, intuitive, top-down framework of aging processes that fosters knowledge-building and collaboration. As the body of knowledge in aging research is rapidly increasing, an open visual encyclopedia of aging processes will be useful to both the new entrants and experts in the field.

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